4th Neuroepigenetics & Neuroepitranscriptomics

Epigenetic mechanisms, including chemical modifications of DNA and histones as well as regulation by non-coding RNAs, are fundamental mechanism regulating gene expression. Various epigenetic mechanisms have pivotal roles in the nervous system and aberrant epigenetic regulation contributes to pathogenesis in many brain disorders. In parallel, epitranscriptomic mechansims cover over 170 different modifications of various RNA. Recent studies have shown diverse role of epitranscriptomic regulation of diverse process in the nervous system, from neurogenesis, learning and memory, to regeneration and cancer. The field is particularly excited by the possibility of clinical translation as shown by the recent profound success in using modified mRNA for COVID 19 vaccine. This meeting will bring together pioneers, experts and junior investigator in studying neuroepigenetics and epitranscriptomics to provide an up-to-date and comprehensive picture of epigenetic and epitranscriptomic mechanisms in neural development, reprogramming and cell identity, plasticity, neuronal function and dysfunction, and discuss future directions of the field. The meeting will offer opportunity and platform for graduate students, postdoctoral fellows, clinical fellows and junior investigator to present their work and interact with leaders in the field and for interdisciplinary collaborations.

Key Sessions
• Epigenetic mechanisms regulating brain development and stem cells
• Transcriptional and translational regulation
• Neuronal specific splicing
• Brain developmental disorders, aging and neurodegeneration
• Single-cell transcriptome, epigenomic, epitranscriptomic, and multi-omics analysis
• Spatial transcriptomic analysis
• 3D epigenome and chromatin topology
• Diverse roles of various RNA modifications in basic neurobiology and clinical translation
• Brain cancer