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Neuroforum 2024 Issue 2
Göttingen Meeting 2025
FENS

Prof. Dr. Frank Kirchhoff

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Univ.-Prof. Dr. Frank Kirchhoff

Präsident


University of Saarland
Molecular Physiology / CIPMM
Center for Integrative Physiology and Molecular Medicine (CIPMM)
University of Saarland
Building 48, 66421 Homburg, Germany

Phone:    +49 6841 16 16440
Fax:    +49 6841 16 16439

Website: https://cipmm.uni-saarland.de/index.php/en/physiology/prof-kirchhoff/res...
E-Mail: frank.kirchhoff@uks.eu

Curriculum Vitae

Date and place of birth    November 1, 1960; Despetal/Barfelde, Germany
since 2009        Adjunct Professor, Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania
since 2021 Adjunct Professor, Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania


Education

1998 Habilitation, Biochemistry, Free University Berlin, Mentors: Prof. Dr. Ferdinand Hucho/Prof. Dr. Helmut Kettenmann
1990 Dr. rer. nat., Neurobiology, Institute for Neurobiology, Heidelberg University, Supervisor: Prof. Dr. Melitta Schachner
1986 Diploma, Biochemistry, University of Hannover, Supervisor: Prof. Dr. Melitta Schachner
1981-1986 Study of Biochemistry, University of Hannover

 

Professional career

2000-2009 Group leader „Glial Physiology and Imaging“, Department of Neurogenetics,Max Planck Institute for Experimental Medicine, Göttingen
1998-2008 Lecturer Free University Berlin
1995-1999 Research Assistant „Cellular Neurosciences“ (Prof. Dr. Helmut Kettenmann), Max Delbrück Center for Molecular Medicine, Berlin
1991-1994 Research Assistant „Cellular Neurobiology“, Institute for Neurobiology, Heidelberg University (PD Dr. Helmut Kettenmann)

 
Honors and Awards

since 2021 Vice president of the German Neuroscience Society (NWG)
2018-2021 Senator of the University of Saarland
since 2016 Member of the Academia Europaea
since 2016 Coordinator EU-H2020-MSCA ITN EU-GliaPhD (a European Graduate Training Network)
since 2014 Visiting Professor at University of Medicine and Pharmacy of Craiova, Craiova, Romania
2013-2021 Coordinator of the Priority Program SPP 1757 „Glial Heterogeneity“ of the German Research Foundation (DFG)
2012-2022 Member of the International Scientific Advisory Committee of the Achucarro Basque Center for Neuroscience, Bilbao, Spain
2010 Offer Full Professorship (W3) for Anatomy, University of Bonn and Group leader at Research Center Caesar (Bonn), declined
since 2009 Member of the Editorial Board „GLIA“
1987-1989 Doctoral scholarship Boehringer Ingelheim Fonds
1981-1986 Scholarship Studienstiftung des deutschen Volkes

    

Reviewing activities

Ad hoc reviewer for scientific journals: European Journal of Neuroscience, Glia, Journal for Neuroscience, Journal of Physiology, Nature, Science, PLoS Biology, Journal of Chemical Neuroanatomy, Journal of Neuroscience Methods, Journal of Neuroscience Research, Molecular and Cellular Neuroscience, Cell Calcium, PLoS One, Science Signaling, eLife

Research Interests

Our research focuses on the molecular and cellular mechanisms of neuron-glia interaction in the central nervous system. We are pursuing the following research questions: How do glial transmitter receptors sense and modulate synaptic transmission? What is the impact for living organisms? How do glial cells respond to acute injuries within the central nervous system?


List of selected publications (>125, H-factor 56), WoS ResearcherID: B-9335-2008, ORCID 0000-0002-2324-2761

  • Fang LP, Zhao N, Caudal LC, Chang HF, Zhao R, Lin CH, Hainz N, Meier C, Bettler B, Huang W, Scheller A, Kirchhoff F, Bai X. (2022) Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior. Nat Commun. 13: 1394. doi: 10.1038/s41467-022-29020-1
  • Laporte MH, Chi KI, Caudal LC, Zhao N, Schwarz Y, Rolland M, Martinez-Hernandez J, Martineau M, Chatellard C, Denarier E, Mercier V, Lemaître F, Blot B, Moutaux E, Cazorla M, Perrais D, Lanté F, Bruns D, Fraboulet S, Hemming FJ, Kirchhoff F, Sadoul R. (2022) Alix is required for activity-dependent bulk endocytosis at brain synapses. PLoS Biol. 20:e3001659. doi: 10.1371/journal.pbio.3001659.
  • Gobbo D, Scheller A, Kirchhoff F. (2021) From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research. Front Neurol. 12:661408.
  • Schweigmann M, Caudal LC, Stopper G, Scheller A, Koch KP, Kirchhoff F. (2021) Versatile Surface Electrodes for Combined Electrophysiology and Two-Photon Imaging of the Mouse Central Nervous System. Front Cell Neurosci. 15: 720675.
  • Caudal LC, Gobbo D, Scheller A, Kirchhoff F (2020) The Paradox of Astroglial Ca2+ Signals at the Interface of Excitation and Inhibition. Front Cell Neurosci. 14: 609947.
  • Huang W, Guo Q, Bai X, Scheller A, Kirchhoff F (2019) Early embryonic NG2 glia are exclusively gliogenic and do not generate neurons in the brain. Glia 67:1094-1103
  • Huang W, Bai X, Stopper L, Catalin B, Cartarozzi LP, Scheller A, Kirchhoff F (2018) During Development NG2 Glial Cells of the Spinal Cord are Restricted to the Oligodendrocyte Lineage, but Generate Astrocytes upon Acute Injury. Neuroscience 385:154-165.
  • Jahn HM, Kasakow CV, Helfer A, Michely J, Verkhratsky A, Maurer HH, Scheller A and Kirchhoff F (2018) Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia. Scientific Reports 8, 5913.
  • Cartarozzi LP, Rieder P, Bai X, Scheller A, Oliveira ALR, Kirchhoff F (2018) In vivo two-photon imaging of motoneurons and adjacent glia in the ventral spinal cord. J Neurosci Methods 299:8-15.
  • Schwarz Y, Zhao N, Kirchhoff F, Bruns D (2017) Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways. Nat Neurosci 20: 1529-1539.
  • Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, Matute C, Löwel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA (2016) Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron 91:119-32.
  • Rudolph R, Jahn HM, Courjaret R, Messemer N, Kirchhoff F, Deitmer JW (2016) The inhibitory input to mouse cerebellar Purkinje cells is reciprocally modulated by Bergmann glial P2Y1 and AMPA receptor signaling. Glia 64: 1265-80.
  • Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, Scheller A, Kirchhoff F (2014) Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development. Glia 62: 896-913.
  • Kettenmann H, Kirchhoff F, Verkhratsky A (2013) Microglia: new roles for the synaptic stripper. Neuron 9: 10-8.
  • Saab AS, Neumeyer A, Jahn HM, Cupido A, Šimek AAM, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI and Kirchhoff F (2012) Bergmann Glial AMPA Receptors are Required for Fine Motor Coordination. Science 337:749-53
  • Dibaj P, Nadrigny F, Steffens H, Scheller A, Hirrlinger J, Schomburg ED, Neusch C, Kirchhoff F (2010) NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia 58:1133-1144.
  • Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F (2009) Split-cre complementation indicates coincident activity of different genes in vivo. Plos One 4:e4286.
  • Hirrlinger PG, Scheller A, Braun C, Hirrlinger J, Kirchhoff F (2006) Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia 54:11-20.
  • Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318.
  • Hirrlinger J, Hulsmann S, Kirchhoff F (2004) Astroglial processes show spontaneous motility at active synaptic terminals in situ. Eur J Neurosci 20:2235-2239.