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Prof. Dr. Stefanie Schirmeier

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Prof. Dr. Stefanie Schirmeier

Kandidatin Sektionssprecherin  "Molekulare Neurobiologie"

TU Dresden
Faculty of Biology, Zoology and Animal Physiology
Zellescher Weg 20b
01217 Dresden
Phone: 0351 463-31922
Email: stefanie.schirmeier@tu-dresden.de

 Copyright des Fotos 'Kretzschmar, TU Dresden'
  Copyright des Fotos "Kretzschmar, TU Dresden"

Curriculum Vitae

Geburtsdatum:  15.05.1983

Children: 2


Career

2002 - 2007 Diploma, Biochemistry, University of Bayreuth
2007 - 2010 Ph. D., Molecular and Cellular Biology, University of Strasbourg, France
2010 - 2015 postdoctoral fellow, Institut für Neuro- und Verhaltensbiologie, WWU Münster, Germany
2015 - 2020 Junior group leader, Institut für Neuro- und Verhaltensbiologie, WWU Münster, Germany
since 01.2021 Professor Zoology and Animal Physiology, TU Dresden, Germany

 

Awards / Stipends

2018 “Nachwuchsförderpreis” of the Universitätsgesellschaft Münster
2010 Thesis prize of the University of Strasbourg for the best theses („prix de thèse 2010“)
2007-2010 Ph. D. thesis scholarship: “Allocation de recherche”: Ministère éducation nationale, enseignement supérieur, recherche


Research focus

My research focuses on understanding how the nutrient homeostasis in the nervous system is regulated and how the different cell types interact metabolically to allow full neuronal function. A special focus lies on the role of glial cells. The aim of my work is to better understand how glial cells and neurons interact to provide sufficient nutrients to support neuronal function and how flexible those interactions can react to perturbations, like for example suboptimal nutrient availability. To understand the cellular changes and regulatory mechanisms, we use genetic manipulations in combination with metabolite live imaging via genetically encoded fluorescent nanosensors, behavioral assays, and different molecular biological methods.

 

 

 

Selected publications

For a complete list see ORCID or google scholar: https://orcid.org/0000-0001-8431-9593; https://scholar.google.de/citations?user=fM9MnrgAAAAJ&hl=de

  • Hertenstein, H., McMullen, E., Weiler, A., Volkenhoff, A., Becker, H. M., & Schirmeier, S. (2021). Starvation-induced regulation of carbohydrate transport at the blood–brain barrier is TGF-β-signaling dependent. ELife 10
  • McMullen E, Weiler A, Becker HM & Schirmeier S (2021) Plasticity of Carbohydrate Transport at the Blood-Brain Barrier. Front. Behav. Neurosci. 14: 271
  • Muralidharan R, Gawali M, Tiwari D, Sukumaran A, Oatman N, Anderson J, Nardini D, Bhuiyan MAN, Tkac I, Ward AL, Kundu M, Waclaw R, Chow L, Gross C, Rao R, Schirmeier S and Dasgupta B (2020). AMPK regulated astrocytic lactate shuttle plays a non-cell autonomous role in neuronal survival. Cell Rep 32, 108092.
  • Sorge S, Theelke J, Yildirim K, Hertenstein H, McMullen E, Müller S, Altbürger C, Schirmeier S & Lohmann I (2020). ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila. Cell Rep 31, 107659.
  • Arce-Molina R, Cortés-Molina F, Sandoval PY, Galaz A, Alegría K, Schirmeier S, Barros LF & San Martín A (2020). A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC ed. James DE. Elife 9, e53917.
  • Volkenhoff A, Hirrlinger J, Kappel JM, Klämbt C, Schirmeier S (2018) Live imaging using a FRET glucose sensor reveals glucose delivery to all cell types in the Drosophila brain. J Insect Physiol 106: 55-64.
  • Volkenhoff A, Weiler A, Letzel M, Stehling M, Klämbt C, Schirmeier S (2015) Glial glycolysis is essential for neuronal survival in Drosophila. Cell Metab 22(3): 437-447.