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Date of birth: 04.05.1964
Education
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1986-1992 |
Medical School, University of Hamburg |
Academic Degrees
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2007 |
W3 Professor for Neurophysiology, Univ Frankfurt |
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1999 |
Master of Arts, University of Oxford |
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1999 |
Habilitation (Physiology), University of Hamburg |
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1992 |
Doctor in Medicine, University of Hamburg (supervisor: Prof. Dr. J.R. Schwarz) |
Professional Career and Academic Achievements
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Since 2008 |
Director, Center of Physiology, Goethe University Frankfurt |
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Since 2007 |
Director (W3), Full Professor (tenure), Institute of Neurophysiology, Goethe University Frankfurt |
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2002-2007 |
Associate Professor (C3, tenure), Department of Physiology, University of Marburg |
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1999-2002 |
Assistant Professor (tenure track), MRC Anatomical Neuropharmacology Unit, University of Oxford, UK (Director Prof. P. Somogyi) |
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1994-1999 |
Research Scientist, Center for Molecular Neurobiology (ZMNH), University of Hamburg (Director Prof. O. Pongs) |
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1992-1994 |
Postdoctoral Fellow, Dept. of Physiology, University of Oxford, UK (Supervisor Prof. FM. Ashcroft) |
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1986-1992 |
Graduate Student, Institute of Physiology, University of Hamburg (Supervisor Prof. J.R. Schwarz) |
Others (editorships, advisory boards, awards)
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2020-2022 |
Board Member, German Physiology Society (DPG) |
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2022 |
Steering Committee Curriculum Development, Medical Faculty, Goethe University Frankfurt |
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2022 |
DPG-Tagungspräsident, Europhysiology 2022, Kopenhagen |
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2021 |
President, 100th Meeting of German Physiological Society, Frankfurt |
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2020 |
Visiting Miller Professorship, UC Berkeley, USA |
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Since 2016 |
Neuroscience Panel for Danish Council for Independent Research (DFF) |
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Since 2015 |
Section Editor European Journal of Neuroscience |
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2015 |
Gutenberg research fellowship, Mainz University |
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2013-2017 |
Reviewing Editor, The Journal of Physiology |
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2013 |
Prize for excellent teaching, Goethe University |
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since 2010 |
Vertrauensdozent, National Scholarship Foundation Germany |
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2004-2010 |
Council Member of International Basal Ganglia Society |
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2004 |
Prize for excellent teaching, Marburg University |
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2001 |
Exhibitor, Royal Society UK |
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1999 |
Senior Fellowship, Exeter College Oxford |
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1992 |
Postdoctoral Fellowship, DFG |
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1991 |
Prize Fellowship, Magdalen College Oxford |
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1991 |
Fellowship, Parkinson Disease Society |
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1985 |
Scholarship, National Scholarship Foundation Germany |
Selected Publications
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Hammer N, Vogel P, Lee S, Roeper J. Eur J Neurosci. 2024 Mar; 59(6):1311-1331. Optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons. doi: 10.1111/ejn.16208. Epub 2023
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Shin J, Kovacheva L, Thomas D, Stojanovic S, Knowlton CJ, Mankel J, Boehm J, Farassat N, Paladini C, Striessnig J, Canavier CC, Geisslinger G, Roeper J. (2022) Cav1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons. Sciences Advances 8:eabm4560.
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Otomo K, Perkins J, Kulkarni A, Stojanovic A, Roeper J*, Paladini CA* (2020) In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons. Nature Communications 11:6286 *shared senior authors
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Cooper A, Butto T, Hammer N, Jagannath S, Fend-Guella D L, Akhtar J, Radyushkin K, Lesage F, Winter J, Strand S, Roeper J*, Zechner U*, Schweiger S* (2020) Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Nature Communications 11:480 *shared senior authors
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Farassat N, Costa K M, Stojanovic S, Albert S, Kovacheva L, Shin J, Egger R, Somayaji M, Duvarci S, Schneider G, Roeper J (2019) In vivo functional diversity of midbrain dopamine neurons within identified axonal projections. eLife 8:e48408
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Duvarci S, Simpson EH, Schneider G, Kandel ER, Roeper J*, Sigurdsson T* (2018) Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression. Nature Communications 2018 9:2822 *shared senior authors
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Subramaniam M, Althof D, Gispert S, Schwenk J, Auburger G, Kulik A, Fakler B, Roeper J (2014) Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels. J Neuroscience 34:13586-99.
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Schiemann J, Schlaudraff F, Klose V, Bingmer M, Seino S, Magill PJ, Zaghloul KA, Schneider G, Liss B, Roeper J (2012) K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nature Neuroscience 15:1272-80.
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Lammel S, Hetzel A, Häckel O, Jones I, Liss B, Roeper J (2008) Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron 2008, 57:760-73.
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Liss B, Haeckel O, Wildmann J, Miki T, Seino S and Roeper J (2005) KATP channels promote differential degeneration of dopaminergic midbrain neurons. Nature Neuroscience 8:1742-51.
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Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S (2001) ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nature Neuroscience 4:507-12.
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Roeper J, Sewing S, Zhang Y, Sommer T, Wanner SG, Pongs O. (1999) NIP domain prevents N-type inactivation in voltage-gated potassium channels. Nature 391:390-3.
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